AKIP1 Gene Summary [Human]
This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | AKIP1 |
| Official Name | A-kinase interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:1170] |
| Ensembl ID | ENSG00000166452 |
| Bio databases IDs | |
| Aliases | A-kinase interacting protein 1 |
| Synonyms | A-kinase interacting protein 1, BCA3, C11orf17, D7H11orf17, D930014E17Rik, ICRFP703B1614Q5.6, ORF27, RGD1306959 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AKIP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
role in cell
- apoptosis
- expression in
- activation in
- phosphorylation in
- binding in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- Mitochondria
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AKIP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- substrate adhesion-dependent cell spreading
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding