ENDOG Gene Summary [Human]
The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ENDOG |
| Official Name | endonuclease G [Source:HGNC Symbol;Acc:HGNC:3346] |
| Ensembl ID | ENSG00000167136 |
| Bio databases IDs | |
| Aliases | endonuclease G |
| Synonyms | ENDONUCLEASE G |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ENDOG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endonuclease
- DNA/RNA non-specific endonuclease
- DNase
- NUC
- protein homodimerization
- enzyme
- protein binding
- magnesium ion binding
Pathways
Biological processes and signaling networks where the ENDOG gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- cardiac hypertrophy
- nonalcoholic fatty liver disease
role in cell
- expression in
- cell death
- production in
- phosphorylation in
- apoptosis
- mass
- size
- autophagy by
- degradation
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- perinuclear region
- Nucleus
- Mitochondria
- mitochondrial matrix
- perikaryon
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ENDOG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- mitochondrial DNA catabolic process
- in utero embryonic development
- apoptotic DNA fragmentation
- positive regulation of apoptotic process
- response to antibiotic
- DNA recombination
- positive regulation of mitochondrial DNA replication
- negative regulation of TOR signaling cascade
- response to DNA damage stimulus
- response to tumor necrosis factor
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- magnesium ion binding
- protein homodimerization activity
- protein binding
- endodeoxyribonuclease activity
- single-stranded DNA specific endodeoxyribonuclease activity
- endoribonuclease activity