PRRX2 Gene Summary [Human]
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PRRX2 |
| Official Name | paired related homeobox 2 [Source:HGNC Symbol;Acc:HGNC:21338] |
| Ensembl ID | ENSG00000167157 |
| Bio databases IDs | |
| Aliases | paired related homeobox 2 |
| Synonyms | paired related homeobox 2, PMX2, PRX2, S8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRRX2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- OAR motif
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- protein domain specific binding
- general RNA polymerase II transcription factor
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- neoplasia
- heat hyperalgesia
- non-insulin-dependent diabetes mellitus
- dyspnea
- osteopenia
- growth failure
- postaxial polydactyly
- cyanosis
- aphagia
role in cell
- expression in
- proliferation
- differentiation
- cell differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRRX2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity