IGFBP6 Gene Summary [Human]
Enables identical protein binding activity and insulin-like growth factor II binding activity. Involved in cell migration and positive regulation of stress-activated MAPK cascade. Part of insulin-like growth factor binary complex. Implicated in obesity. Biomarker of breast cancer; in situ carcinoma; leiomyoma; and neovascular inflammatory vitreoretinopathy. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | IGFBP6 |
| Official Name | insulin like growth factor binding protein 6 [Source:HGNC Symbol;Acc:HGNC:5475] |
| Ensembl ID | ENSG00000167779 |
| Bio databases IDs | |
| Aliases | insulin like growth factor binding protein 6 |
| Synonyms | IBP6, insulin-like growth factor binding protein 6, RBP6A, RBP6G |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IGFBP6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IGF-binding site
- TY
- signal peptide
- insulin-like growth factor binding
- linker domain
- central domain
- protein binding
- receptor binding
- Insulin-like growth factor binding protein
- identical protein binding
Pathways
Biological processes and signaling networks where the IGFBP6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- gastrointestinal neoplasia
- upper aerodigestive tract cancer
- gastrointestinal tract cancer
- digestive system cancer
- endometrial cancer
- breast carcinoma
role in cell
- apoptosis
- proliferation
- activation in
- quantity
- migration
- differentiation
- synthesis in
- tyrosine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- apical compartment
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IGFBP6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- signal transduction
- negative regulation of cell proliferation
- positive regulation of MAPK cascade
- regulation of insulin-like growth factor receptor signaling pathway
- cell migration
- positive regulation of stress-activated MAPK cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- insulin-like growth factor binary complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- fibronectin binding
- receptor binding
- insulin-like growth factor I binding
- insulin-like growth factor II binding