FOXA3 Gene Summary [Human]
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FOXA3 |
| Official Name | forkhead box A3 [Source:HGNC Symbol;Acc:HGNC:5023] |
| Ensembl ID | ENSG00000170608 |
| Bio databases IDs | |
| Aliases | forkhead box A3 |
| Synonyms | FKHH3, forkhead box A3, HNF3, HNF3G, Hnf3 Gamma, Hnf3 γ, TCF3G |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FOXA3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- FH_FOX
- nucleic acid binding
- double-stranded DNA binding
- alpha helix
- protein binding
- sequence-specific DNA binding
- transcription factor activity
- DNA binding
- Forkhead domain
- FORKHEAD
Pathways
Biological processes and signaling networks where the FOXA3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- obesity
- bronchiolo-alveolar adenocarcinoma
- broncho-alveolar lung cancer
- metaplasia
- steatohepatitis
- endometriosis
- respiratory disorder
- coronary artery disease
- COVID-19
role in cell
- proliferation
- expression in
- cell viability
- binding in
- differentiation
- invasiveness
- homeostasis
- transactivation in
- transcription in
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- actin cytoskeleton
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FOXA3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular glucose homeostasis
- spermatogenesis
- cell differentiation
- transcription from RNA polymerase II promoter
- anatomical structure morphogenesis
- cellular response to starvation
- positive regulation of transcription from RNA polymerase II promoter
- chromatin organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- actin cytoskeleton
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity