PTCRA Gene Summary [Human]
The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Details
| Type | Protein Coding |
| Official Symbol | PTCRA |
| Official Name | pre T cell antigen receptor alpha [Source:HGNC Symbol;Acc:HGNC:21290] |
| Ensembl ID | ENSG00000171611 |
| Bio databases IDs | |
| Aliases | pre T cell antigen receptor alpha |
| Synonyms | gp33, IMD126, PRETALPHA, pre T-cell antigen receptor alpha, pre T-cell antigen receptor α, PRET-α, PTA, pT[a], PT-ALPHA, pT-alpha-TCR, PT-α, pT-α-TCR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTCRA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- alpha connecting peptide motif
- cytoplasmic domain
- transmembrane domain
- Pre-T-cell antigen receptor
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- susceptibility to immunodeficiency-126
- coronary artery disease
- leukemogenesis
- hypoplasia
- diabetic nephropathy
- pemphigus vulgaris
- ZMYM2-FGFR1 induced stem cell leukemia lymphoma syndrome
role in cell
- apoptosis
- expression in
- differentiation
- growth
- production in
- development
- number
- expansion
- quantity
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- lysosome
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTCRA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of thymocyte apoptotic process
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding