Ptcra Gene Summary [Mouse]
Acts upstream of or within negative regulation of thymocyte apoptotic process. Predicted to be located in plasma membrane. Is expressed in thymus and thymus primordium. Orthologous to human PTCRA (pre T cell antigen receptor alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptcra |
| Official Name | pre T cell antigen receptor alpha [Source:MGI Symbol;Acc:MGI:104857] |
| Ensembl ID | ENSMUSG00000036858 |
| Bio databases IDs | |
| Aliases | pre T cell antigen receptor alpha |
| Synonyms | gp33, IMD126, PRETALPHA, pre T-cell antigen receptor alpha, pre T-cell antigen receptor α, PRET-α, PTA, pT[a], PT-ALPHA, pT-alpha-TCR, PT-α, pT-α-TCR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptcra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- alpha connecting peptide motif
- cytoplasmic domain
- transmembrane domain
- Pre-T-cell antigen receptor
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- susceptibility to immunodeficiency-126
- coronary artery disease
- leukemogenesis
- hypoplasia
- diabetic nephropathy
- pemphigus vulgaris
- ZMYM2-FGFR1 induced stem cell leukemia lymphoma syndrome
role in cell
- apoptosis
- expression in
- differentiation
- growth
- production in
- development
- number
- expansion
- quantity
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- lysosome
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptcra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of thymocyte apoptotic process
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding