PDE12 Gene Summary [Human]
Enables 3'-5'-exoribonuclease activity. Involved in several processes, including RNA metabolic process; cellular response to cytokine stimulus; and regulation of mitochondrial mRNA stability. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PDE12 |
| Official Name | phosphodiesterase 12 [Source:HGNC Symbol;Acc:HGNC:25386] |
| Ensembl ID | ENSG00000174840 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 12, 2'-phosphodiesterase, mitochondrial deadenylase |
| Synonyms | 2-PDE, 2'-PDE, E430028B21Rik, LOC102724626, LRRGT00074, phosphodiesterase 12, RGD1310975 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDE12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'-5' exoribonuclease
- poly(A)-specific ribonuclease
- exonuclease
- ribonuclease
- oligonucleotidase
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- Endonuclease/Exonuclease/phosphatase family
- enzyme
Pathways
Biological processes and signaling networks where the PDE12 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDE12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitochondrial mRNA stability
- nucleic acid metabolic process
- mitochondrial mRNA catabolic process
- cellular response to dsRNA
- defense response to virus
- cellular response to interferon-gamma
- mRNA processing
- positive regulation of viral genome replication
- cellular response to interferon-alpha
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- poly(A)-specific ribonuclease activity
- 3'-5'-exoribonuclease activity
- metal ion binding
- exonuclease activity
- oligoribonucleotidase activity