P2RY14 Gene Summary [Human]
The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | P2RY14 |
| Official Name | purinergic receptor P2Y14 [Source:HGNC Symbol;Acc:HGNC:16442] |
| Ensembl ID | ENSG00000174944 |
| Bio databases IDs | |
| Aliases | purinergic receptor P2Y14 |
| Synonyms | A330108O13Rik, BPR105, GPR105, P2Y14, purinergic receptor P2Y14, purinergic receptor P2Y, G-protein coupled, 14, UDP-glucose receptor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human P2RY14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the P2RY14 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- insomnia
- primary gout
- uterine serous papillary cancer
- impaired glucose tolerance
- COVID-19
role in cell
- growth
- expression in
- phosphorylation in
- apoptosis
- activation in
- formation
- NETosis
- cellular infiltration by
- cisplatin sensitivity
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human P2RY14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- G-protein coupled purinergic nucleotide receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled purinergic nucleotide receptor activity
- UDP-activated nucleotide receptor activity