Tubb6 Gene Summary [Mouse]
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in intercellular bridge and mitotic spindle. Predicted to be active in cytoplasm and microtubule. Is expressed in several structures, including brain; foregut; ganglia; genitourinary system; and retina. Orthologous to human TUBB6 (tubulin beta 6 class V). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tubb6 |
| Official Name | tubulin, beta 6 class V [Source:MGI Symbol;Acc:MGI:1915201] |
| Ensembl ID | ENSMUSG00000001473 |
| Bio databases IDs | |
| Aliases | tubulin, beta 6 class V |
| Synonyms | 2310057H16Rik, BB220206, FPVEPD, HsT1601, MGC4083, RGD1305887, TUBB-5, Tubulin Beta 5, tubulin beta 6 class V, tubulin, beta 6 class V, Tubulin β 5, tubulin β 6 class V, tubulin, β 6 class V |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tubb6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tubulin protein family of FtsZ and CetZ-like
- Tubulin C-terminal domain
- Tubulin/FtsZ family, GTPase domain
- protein binding
- Tubulin/FtsZ family, C-terminal domain
Pathways
Biological processes and signaling networks where the Tubb6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- ptosis
- congenital facial palsy with ptosis and velopharyngeal dysfunction
- optic atrophy
role in cell
- pyroptosis
- disruption
- disruption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- Nucleus
- microtubules
- cytoplasmic bridges
- cytosol
- synaptosomes
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tubb6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule cytoskeleton organization
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- microtubule cytoskeleton
- extracellular vesicular exosome
- mitotic spindle
- cytoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- metal ion binding
- GTPase activity
- structural constituent of cytoskeleton