NLRP11 Gene Summary [Human]
This gene is a member of the the NOD-like receptor protein (NLRP) gene family and encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene has been shown to regulate caspases in the proinflammatory signal transduction pathway and, based on studies of other members of the NLRP gene family with similar domain structure, is predicted to form part of the multiprotein inflammasome complex. Alternative splicing produces multiple transcript variants encoding distince isoforms. [provided by RefSeq, May 2017]
Details
| Type | Protein Coding |
| Official Symbol | NLRP11 |
| Official Name | NLR family pyrin domain containing 11 [Source:HGNC Symbol;Acc:HGNC:22945] |
| Ensembl ID | ENSG00000179873 |
| Bio databases IDs | |
| Aliases | NLR family pyrin domain containing 11, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 11 |
| Synonyms | CLR19.6, NALP11, NLR family pyrin domain containing 11, NOD17, PAN10, PYPAF6, PYPAF7 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NLRP11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NLRC4 helical domain HD2
- PAAD/DAPIN/Pyrin domain
- protein phosphatase 1 regulatory subunit 42
- linker domain
- NACHT domain
- Death Domain Superfamily of protein-protein interaction domains
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the NLRP11 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- multiple sclerosis
regulated by
- poly rI:rC-RNA
- HeLa cells
- MAVS
- MCC950
- THP-1 cells
- IFN beta
role in cell
- production in
- apoptosis
- phosphorylation in
- activation in
- expression in
- binding in
- cell death
- degradation in
- transactivation in
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NLRP11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of inflammatory response
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- RNA binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen