CHRM5
CHRM5 Gene Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CHRM5 |
| Official Name | cholinergic receptor muscarinic 5 [Source:HGNC Symbol;Acc:HGNC:1954] |
| Ensembl ID | ENSG00000184984 |
| Bio databases IDs | |
| Aliases | cholinergic receptor muscarinic 5, acetylcholine receptor, muscarinic 5 |
| Synonyms | AChR-M5,cholinergic receptor muscarinic 5,cholinergic receptor, muscarinic 5,HM5,M5,M5 mAChR,M5 MUSCARINIC receptor,M5R |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled acetylcholine receptor
- intracellular loop
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- glycine-gated chloride channel
Pathways
Biological processes and signaling networks where the CHRM5 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SLC6A8
- AGAP1
- SLC5A6
- MAP3K1
- ATP2A2
- RTN1
- EPB41L1
- REEP5
- tolterodine
- TMEM161A
disease
- traumatic brain injury
- stroke
- Alzheimer disease
- constipation
- cancer
- COVID-19
- plasma cell myeloma
- schizophrenia
- chronic obstructive pulmonary disease
- eating disorder
regulated by
- hyoscyamine
- carbamylcholine
- clozapine
- darifenacin
- trihexyphenidyl
- thioridazine
- CD40LG
- acetylcholine
- AGAP1
- thiochrome
regulates
- heavy metal
- dopamine
- Ca2+
- phosphatidylinositol
- CNR1
- histamine
- GNAQ/11
- GNA11
- TRPC3
- GNAQ
role in cell
- activation in
- proliferation
- growth
- transformation
- size
- morphology
- transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- neurites
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CHRM5 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- gastric acid secretion
- dopamine transport
- adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- synaptic transmission
- G-protein coupled acetylcholine receptor signaling pathway
- transmission of nerve impulse
- regulation of phosphatidylinositol dephosphorylation
CELLULAR COMPONENT
Where in the cell the gene product is active
- dendrite
- postsynaptic membrane
- synapse
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- protein binding
- G-protein coupled acetylcholine receptor activity
- serotonin receptor activity