SEMA4C Gene Summary [Human]
Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in muscle cell differentiation and positive regulation of stress-activated MAPK cascade. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SEMA4C |
| Official Name | semaphorin 4C [Source:HGNC Symbol;Acc:HGNC:10731] |
| Ensembl ID | ENSG00000168758 |
| Bio databases IDs | |
| Aliases | semaphorin 4C, M-Sema F |
| Synonyms | AI426163, M-SEMA-F, RGD1562837, SEMACL1, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C, SEMAF, SEMAI, semaphorin 4C |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SEMA4C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- cytoplasmic domain
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Sema domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the SEMA4C gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- breast cancer
- metastasis
- secondary neoplasm
- cervical cancer
- osteosarcomagenesis
- diabetic nephropathy
- systemic autoimmune syndrome
role in cell
- growth
- expression in
- proliferation
- phosphorylation in
- signaling in
- migration
- differentiation
- wound closure by
- colony formation by
- G1 phase in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- glutaminergic synapse
- cellular membrane
- synaptic membrane
- neurites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SEMA4C gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative chemotaxis
- neural tube closure
- neural crest cell migration
- cerebellum development
- muscle cell differentiation
- axon guidance
- cell migration in hindbrain
- positive regulation of stress-activated MAPK cascade
- semaphorin-plexin signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- extracellular space
- synaptic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- chemorepellent activity
- semaphorin receptor binding