METTL9 Gene Summary [Human]
Enables protein-L-histidine N-pros-methyltransferase activity. Predicted to be involved in methylation. Is active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | METTL9 |
| Official Name | methyltransferase like 9 [Source:HGNC Symbol;Acc:HGNC:24586] |
| Ensembl ID | ENSG00000197006 |
| Bio databases IDs | |
| Aliases | methyltransferase like 9, DORA reverse strand protein 1 |
| Synonyms | 0610012D09RIK, CGI-81, D3Mgi28, DREV, DREV1, hMETTL9, methyltransferase 9, His-X-His N1(pi)-histidine, methyltransferase like 9, Mettl9b, mMETTL9, MNCb-5680, PAP1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human METTL9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein methyltransferase
- DREV methyltransferase
- enzyme
- protein binding
- AdoMet_MTases
- S-adenosylmethionine-dependent methyltransferase
- methyltransferase domain
- N-methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Huntington disease
- major depression
- male pattern hair loss
- psoriatic arthritis
role in cell
- generation in
- methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human METTL9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- methylation
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding