SUCNR1
SUCNR1 Gene Summary
This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | SUCNR1 |
| Official Name | succinate receptor 1 [Source:HGNC Symbol;Acc:HGNC:4542] |
| Ensembl ID | ENSG00000198829 |
| Bio databases IDs | |
| Aliases | succinate receptor 1 |
| Synonyms | GPR91,succinate receptor 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- signaling receptor activity
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the SUCNR1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- LAMP2
- TMEM14B
- SH3GLB1
- PRMT8
- MTCH2
disease
- hepatic steatosis
- choroidal neovascularization
- oxygen-induced retinopathy
- renal clear cell adenocarcinoma
- renal clear cell cancer
regulated by
- lipopolysaccharide
- GATA2
- TWF1
- IL1B
- GPD1
- SLC25A13
- succinic acid
- heavy metal
- SIRT3
- RICTOR
regulates
- Ca2+
- oxygen
- cyclic AMP
- VEGF
- IL1B
- Cxcl10
- COL1A1
- COL3A1
- ACTA2
- LDH (family)
role in cell
- function
- activation
- production in
- proliferation
- chemotaxis
- phagocytosis by
- phagocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SUCNR1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of angiotensin metabolic process
- G-protein coupled receptor signaling pathway
- response to calcium ion
- glucose homeostasis
- positive regulation of inflammatory response
- macrophage activation involved in immune response
- energy homeostasis
- renin secretion into blood stream
- positive regulation of chemotaxis
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- signaling receptor activity