HSPA1A Gene Summary [Human]
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HSPA1A |
| Official Name | heat shock protein family A (Hsp70) member 1A [Source:HGNC Symbol;Acc:HGNC:5232] |
| Ensembl ID | ENSG00000204389 |
| Bio databases IDs | |
| Aliases | heat shock protein family A (Hsp70) member 1A |
| Synonyms | heat shock protein 1A, heat shock protein family A (Hsp70) member 1A, HEL-S-103, hsp68, HSP70, Hsp70-1, HSP70.1, HSP70-1A, HSP70-2, HSP70.2, Hsp70-3, Hsp70.3, HSP70A, hsp70A1, HSP70I, HSP72, HSPA1, IHSP70 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HSPA1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MreB/Mbl protein
- ATP-binding domain
- transcription co-repressor
- heat shock protein binding
- G-protein-coupled receptor binding
- ATP binding
- peptide-binding domain
- enzyme
- ATPase
- nucleotide-binding domain
- double-stranded RNA binding
- Hsp70 protein
- ubiquitin protein ligase binding
- protease binding
- NF-kappaB binding
- nuclear localization sequence
- enzyme binding
- histone deacetylase binding
- protein domain specific binding
- protein binding
- receptor binding
- Fe-S protein assembly chaperone HscA
- chaperone protein DnaK
- receptor agonist activity
- substrate binding domain
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the HSPA1A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- Huntington disease
- tremor
- melanoma
- melanoma cancer
- tumorigenesis
- mitral valve prolapse
- cataract
- human papilloma virus infection
role in cell
- expression in
- survival
- proliferation
- morphology
- necrosis
- apoptosis
- cell death
- phosphorylation in
- growth
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- aggresome
- ficolin-1-rich granule lumen
- Extracellular Space
- intracellular space
- perinuclear region
- Nucleus
- Plasma Membrane
- centrosome
- Endoplasmic Reticulum
- centriole
- Mitochondria
- cytosol
- apical membrane
- basolateral membrane
- mitochondrial nucleoids
- nucleoplasm
- nucleoli
- nuclear speckles
- membrane rafts
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HSPA1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- positive regulation of RNA splicing
- negative regulation of cell proliferation
- mRNA catabolic process
- response to unfolded protein
- positive regulation of erythrocyte differentiation
- positive regulation of NF-kappaB transcription factor activity
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to heat
- negative regulation of cell growth
- cellular response to unfolded protein
- regulation of protein ubiquitination
- negative regulation of protein ubiquitination
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- signal transduction
- lysosomal transport
- chaperone mediated protein folding requiring cofactor
- positive regulation of microtubule nucleation
- protein refolding
- negative regulation of inclusion body assembly
- cellular response to steroid hormone stimulus
- positive regulation of interleukin-8 production
- cellular heat acclimation
- negative regulation of apoptotic process
- positive regulation of gene expression
- chaperone-mediated protein complex assembly
- ATP metabolic process
- positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
- cellular response to oxidative stress
- protein stabilization
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nuclear speck
- endoplasmic reticulum
- extracellular region
- nucleoplasm
- nucleus
- extracellular space
- centrosome
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- focal adhesion
- cytoplasm
- centriole
- mitochondrion
- blood microparticle
- cytosol
- vesicle
- macromolecular complex
- inclusion body
- signalosome
- aggresome
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- heat shock protein binding
- histone deacetylase binding
- C3HC4-type RING finger domain binding
- receptor agonist activity
- unfolded protein binding
- receptor binding
- G-protein coupled receptor binding
- ATP binding
- RNA binding
- ubiquitin protein ligase binding
- protein binding involved in protein folding
- protein binding
- transcription corepressor activity
- cadherin binding
- viral receptor activity
- denatured protein binding
- misfolded protein binding
- enzyme binding