LTB Gene Summary [Human]
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LTB |
| Official Name | lymphotoxin beta [Source:HGNC Symbol;Acc:HGNC:6711] |
| Ensembl ID | ENSG00000204487 |
| Bio databases IDs | |
| Aliases | lymphotoxin beta |
| Synonyms | LOC103694381, LTbeta, Lt β, Lymphotoxin B, LYMPHOTOXIN beta, LYMPHOTOXIN β, p33, TNFC, TNFSF3, TNLG1C |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LTB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytokine binding
- TNF
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the LTB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- colitis
- breast cancer
- primary biliary cirrhosis
role in cell
- expression in
- cell death
- apoptosis
- activation in
- proliferation
- adhesion
- formation
- cellular infiltration by
- generation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LTB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of interleukin-12 production
- immune response
- signal transduction
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- cell-cell signaling
- gene expression
- positive regulation of extrinsic apoptotic signaling pathway
- lymph node development
- skin development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- tumor necrosis factor receptor binding
- cytokine activity
- receptor binding