Ltb Gene Summary [Mouse]
Predicted to enable cytokine activity. Involved in positive regulation of interleukin-12 production. Acts upstream of or within gene expression; lymph node development; and skin development. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including brain; hemolymphoid system; liver; lung; and reproductive system. Orthologous to human LTB (lymphotoxin beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ltb |
| Official Name | lymphotoxin B [Source:MGI Symbol;Acc:MGI:104796] |
| Ensembl ID | ENSMUSG00000024399 |
| Bio databases IDs | |
| Aliases | lymphotoxin B |
| Synonyms | LOC103694381, LTbeta, Lt β, Lymphotoxin B, LYMPHOTOXIN beta, LYMPHOTOXIN β, p33, TNFC, TNFSF3, TNLG1C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ltb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytokine binding
- TNF
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the Ltb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Dendritic Cell Maturation
- Erythropoietin Signaling
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-17 Signaling
- Lymphotoxin β Receptor Signaling
- RAR Activation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- colitis
- breast cancer
- primary biliary cirrhosis
role in cell
- expression in
- cell death
- apoptosis
- activation in
- proliferation
- adhesion
- formation
- cellular infiltration by
- generation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ltb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of interleukin-12 production
- immune response
- signal transduction
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- cell-cell signaling
- gene expression
- positive regulation of extrinsic apoptotic signaling pathway
- lymph node development
- skin development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- tumor necrosis factor receptor binding
- cytokine activity
- receptor binding