IGHE Gene Summary [Human]
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Predicted to be located in extracellular region. Predicted to be part of immunoglobulin complex, circulating. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Immunoglobulin Constant Gene |
| Official Symbol | IGHE |
| Official Name | immunoglobulin heavy constant epsilon [Source:HGNC Symbol;Acc:HGNC:5522] |
| Ensembl ID | ENSG00000211891 |
| Bio databases IDs | |
| Aliases | immunoglobulin heavy constant epsilon |
| Synonyms | C epsilon, C ε, epsilon GLT, epsilon IG H, I epsilon, I epsilon-C epsilon, IgE, IgE-Fc, IG epsilon, IGH2, Igh-7, IG ε, immunoglobulin heavy constant epsilon, immunoglobulin heavy constant ε, I ε, I ε-C ε, ε GLT, ε IG H |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IGHE often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IgE-Fc domain
- extracellular membrane-proximal domain
- heavy chain domain, constant
- protein binding
- receptor binding
- constant domain
Pathways
Biological processes and signaling networks where the IGHE gene in human plays a role, providing insight into its function and relevance in health or disease.
- Airway Inflammation in Asthma
- B Cell Receptor Signaling
- Communication between Innate and Adaptive Immune Cells
- Fc Epsilon RI Signaling
- FcγRIIB Signaling in B Lymphocytes
- IL-15 Signaling
- IL-4 Signaling
- p70S6K Signaling
- Phagosome Formation
- PI3K Signaling in B Lymphocytes
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- allergic rhinitis
- nasal polyp
- allergic asthma
- asthma
- atopic dermatitis
- severe persistent asthma
- pulmonary disease
- passive cutaneous anaphylaxis
- chronic urticaria
- urticaria
role in cell
- cellular infiltration by
- apoptosis
- proliferation
- recruitment
- activation
- function
- degranulation
- differentiation
- formation
- inflammatory response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IGHE gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- immune response
- complement activation, classical pathway
- adaptive immune response
- antibacterial humoral response
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- immunoglobulin complex, circulating
- IgE immunoglobulin complex
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- antigen binding
- immunoglobulin receptor binding