IGHG4 Gene Summary [Human]
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Immunoglobulin Constant Gene |
| Official Symbol | IGHG4 |
| Official Name | immunoglobulin heavy constant gamma 4 (G4m marker) [Source:HGNC Symbol;Acc:HGNC:5528] |
| Ensembl ID | ENSG00000211892 |
| Bio databases IDs | |
| Aliases | immunoglobulin heavy constant gamma 4 (G4m marker) |
| Synonyms | IGG4, immunoglobulin heavy constant gamma 4 (G4m marker), immunoglobulin heavy constant γ 4 (G4m marker) |
| Species | Human, Homo sapiens |
Pathways
Biological processes and signaling networks where the IGHG4 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Autoimmune Thyroid Disease Signaling
- B Cell Receptor Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- FcγRIIB Signaling in B Lymphocytes
- IL-12 Signaling and Production in Macrophages
- IL-15 Signaling
- p70S6K Signaling
- Phagosome Formation
- PI3K Signaling in B Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
- primary cancer
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- prostate cancer
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- primary cutaneous marginal zone B-cell lymphoma
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IGHG4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation, classical pathway
- adaptive immune response
- antibacterial humoral response
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- immunoglobulin complex, circulating
- blood microparticle
- extracellular region
- plasma membrane
- IgG immunoglobulin complex
Molecular Function
What the gene product does at the molecular level
- antigen binding
- immunoglobulin receptor binding