CRIP1 Gene Summary [Human]
Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008]
Details
| Type | Retained Intron |
| Official Symbol | CRIP1 |
| Official Name | cysteine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:2360] |
| Ensembl ID | ENSG00000213145 |
| Bio databases IDs | |
| Aliases | cysteine rich protein 1 |
| Synonyms | CRHP, CRIP, CRP-1, Cysteine-rich intestinal, cysteine-rich protein 1, LOC686293 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CRIP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycine rich domain
- peptide binding
- zinc ion binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- epithelial cancer
- neoplasia
- organismal death
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- psoriasis
- peritoneal endometriosis
- colon cancer
- liver cancer
role in cell
- accumulation in
- formation
- degradation in
- tumorigenicity
- response by
- sphere formation by
- branching
- ubiquitination in
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CRIP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to UV-B
- heart development
- response to zinc ion
- immune response
- regulation of gene expression
- DNA damage response, signal transduction resulting in induction of apoptosis
- cellular response to antibiotic
- prostate gland stromal morphogenesis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- peptide binding