USP51 Gene Summary [Human]
Enables chromatin binding activity; histone binding activity; and thiol-dependent deubiquitinase. Involved in histone deubiquitination; regulation of cell cycle process; and regulation of double-strand break repair. Predicted to be located in chromosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | USP51 |
| Official Name | ubiquitin specific peptidase 51 [Source:HGNC Symbol;Acc:HGNC:23086] |
| Ensembl ID | ENSG00000247746 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 51 |
| Synonyms | RGD1562211, ubiquitin specific peptidase 51, ubiquitin specific protease 51 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP51 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin thiolesterase
- histone binding
- Zn-finger in ubiquitin-hydrolases and other protein
- peptidase
- Ubiquitin carboxyl-terminal hydrolase
- ubiquitin-specific protease
- chromatin binding
- enzyme
- Peptidase_C19
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the USP51 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USP51 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- regulation of double-strand break repair via nonhomologous end joining
- proteolysis
- regulation of double-strand break repair via homologous recombination
- response to DNA damage stimulus
- regulation of cell cycle process
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- zinc ion binding
- histone binding
- chromatin binding