AATF Gene Summary [Human]
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | AATF |
| Official Name | apoptosis antagonizing transcription factor [Source:HGNC Symbol;Acc:HGNC:19235] |
| Ensembl ID | ENSG00000275700 |
| Bio databases IDs | |
| Aliases | apoptosis antagonizing transcription factor |
| Synonyms | 4933415H02Rik, 5830465M17Rik, apoptosis antagonizing transcription factor, BFR2, CHE-1, DED, Trb |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AATF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Apoptosis-antagonizing transcription factor, C-terminal
- transcription regulator
- protein kinase binding
- Apoptosis antagonizing transcription factor
- tau protein binding
- LRR-domain binding
- nuclear localization sequence
- leucine zipper domain
- protein binding
- phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- apoptosis
- activation in
- binding in
- expression in
- growth
- adhesion
- proliferation
- processing in
- transmembrane potential
- biogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- pre-ribosome
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AATF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryonic cleavage
- positive regulation of transcription, DNA-dependent
- ribosomal small subunit biogenesis
- cell adhesion
- regulation of mitotic cell cycle
- negative regulation of apoptotic signaling pathway
- negative regulation of amyloid precursor protein biosynthetic process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- small-subunit processome
- cytoplasm
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- RNA binding
- protein binding
- tau protein binding
- leucine zipper domain binding