MIR146A Gene Summary [Human]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. Some of the targets of the encoded miRNA are the transcripts for tumor necrosis factor, interleukin 1 receptor-associated kinase 1, interleukin 1-beta, TNF receptor-associated factor 6, and complement factor H. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2015]
Details
| Type | Micro RNA |
| Official Symbol | MIR146A |
| Official Name | microRNA 146a [Source:HGNC Symbol;Acc:HGNC:31533] |
| Ensembl ID | ENSG00000283733 |
| Bio databases IDs | |
| Aliases | microRNA 146a |
| Synonyms | hsa-miR-146, hsa-miR-146a, HSA-MIR-146B, microRNA 146, microRNA 146a, microRNA 146B, MIR146A, MIR146B, MIRN146, MIRN146A, MIRN146B, miRNA146A, miRNA146B, mmu-miR-146, mmu-miR-146a, mmu-miR-146b, pre-miR-146b, pri-miR-146b, rno-miR-146, rno-miR-146a, rno-miR-146b |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MIR146A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- translation repressor
- mRNA binding
- microRNA
Pathways
Biological processes and signaling networks where the MIR146A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anemia
- kainic acid-induced epileptic seizure
- metastasis
- neoplasia
- cervical squamous cell carcinoma
- cancer
- psoriasis
- colorectal cancer
- epithelial cancer
- cutaneous melanoma cancer
role in cell
- proliferation
- activation in
- phosphorylation in
- expression in
- cell viability
- growth
- invasion by
- cell death
- cytotoxicity
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- synapse
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MIR146A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- positive regulation of neuron differentiation
- positive regulation of fibroblast growth factor receptor signaling pathway
- negative regulation of cytokine production involved in inflammatory response
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of tyrosine phosphorylation of STAT protein
- positive regulation of cell migration involved in sprouting angiogenesis
- negative regulation of cell migration involved in sprouting angiogenesis
- negative regulation of monocyte extravasation
- cellular response to glucose stimulus
- regulation of stem cell differentiation
- positive regulation of cellular senescence
- cellular response to hypoxia
- mRNA cleavage involved in gene silencing by miRNA
- negative regulation of glial cell proliferation
- negative regulation of cell adhesion molecule production
- negative regulation of translation involved in gene silencing by miRNA
- negative regulation of SMAD protein import into nucleus
- negative regulation of toll-like receptor 4 signaling pathway
- gene silencing by miRNA
- negative regulation of inflammatory response
- regulation of toll-like receptor signaling pathway
- I-kappaB kinase/NF-kappaB cascade
- negative regulation of interleukin-6 production
- negative regulation of gene expression
- cellular response to lipopolysaccharide
- negative regulation of interleukin-8 production
- positive regulation of gene expression
- innate immune response
- positive regulation of apoptotic process
- negative regulation of dephosphorylation
- cellular response to cytokine stimulus
- negative regulation of endothelial cell proliferation
- negative regulation of chemokine (C-X-C motif) ligand 2 production
- interleukin-1-mediated signaling pathway
- negative regulation of cholesterol storage
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- mRNA 3'-UTR binding