Cdh4 Gene Summary [Mouse]

This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. The encoded protein is involved in retinal angiogenesis during development where it plays a crucial role in the endothelial-astrocyte interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

Details

Type
Protein Coding
Official Symbol
Cdh4
Official Name
cadherin 4 [Source:MGI Symbol;Acc:MGI:99218]
Ensembl ID
ENSMUSG00000000305
Bio databases IDs NCBI: 12561 Ensembl: ENSMUSG00000000305
Aliases cadherin 4
Synonyms AW120700, CAD4, cadherin 4, Cdh4l, FLJ22202, LOC101928097, LOC102554066, LOC311710, R-CAD, R-Cadh
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdh4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Cadherin, Y-type LIR-motif
  • Cadherin prodomain like
  • Cadherin repeat-like domain

Pathways

Biological processes and signaling networks where the Cdh4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • COVID-19
  • prostate cancer
  • migraines
  • restless legs syndrome
  • femoral fracture
  • obstructive sleep apnea
  • bipolar disorder
  • mixed connective tissue disease
  • multiple system atrophy
  • subjective cognitive decline
regulated by
regulates
role in cell
  • expression in
  • cell death
  • proliferation
  • invasion by
  • migration
  • adhesion
  • motility
  • colonization by
  • formation by
  • morphogenesis by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane
  • cell-cell contacts
  • cytosol
  • anchoring junction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdh4 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • calcium-dependent cell-cell adhesion
  • adherens junction organization
  • cell-cell junction assembly
  • multicellular organismal development
  • cell morphogenesis
  • heterophilic cell-cell adhesion
  • axon guidance
  • positive regulation of axon extension
  • cell adhesion
  • homophilic cell adhesion
  • axon extension
  • cell-cell adhesion mediated by cadherin
  • cell migration

Cellular Component

Where in the cell the gene product is active
  • adherens junction
  • catenin complex
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • calcium ion binding
  • cadherin binding
  • beta-catenin binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.