Cdh4 Gene Summary [Rat]
Predicted to enable calcium ion binding activity. Predicted to act upstream of or within several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and positive regulation of axon extension. Predicted to be located in plasma membrane. Orthologous to human CDH4 (cadherin 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdh4 |
| Official Name | cadherin 4 [Source:RGD Symbol;Acc:621091] |
| Ensembl ID | ENSRNOG00000052405 |
| Bio databases IDs | |
| Aliases | cadherin 4 |
| Synonyms | AW120700, CAD4, cadherin 4, Cdh4l, FLJ22202, LOC101928097, LOC102554066, LOC311710, R-CAD, R-Cadh |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdh4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cadherin, Y-type LIR-motif
- Cadherin prodomain like
- Cadherin repeat-like domain
Pathways
Biological processes and signaling networks where the Cdh4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- prostate cancer
- migraines
- restless legs syndrome
- femoral fracture
- obstructive sleep apnea
- bipolar disorder
- mixed connective tissue disease
- multiple system atrophy
- subjective cognitive decline
role in cell
- expression in
- cell death
- proliferation
- invasion by
- migration
- adhesion
- motility
- colonization by
- formation by
- morphogenesis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- cell-cell contacts
- cytosol
- anchoring junction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdh4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium-dependent cell-cell adhesion
- adherens junction organization
- cell-cell junction assembly
- multicellular organismal development
- cell morphogenesis
- heterophilic cell-cell adhesion
- axon guidance
- positive regulation of axon extension
- cell adhesion
- homophilic cell adhesion
- axon extension
- cell-cell adhesion mediated by cadherin
- cell migration
Cellular Component
Where in the cell the gene product is active
- adherens junction
- catenin complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- cadherin binding
- beta-catenin binding