Chmp1a Gene Summary [Mouse]
Predicted to enable protein domain specific binding activity and protein homodimerization activity. Predicted to be involved in several processes, including midbody abscission; regulation of cell cycle process; and vacuolar transport. Predicted to act upstream of or within mitotic chromosome condensation and negative regulation of gene expression. Predicted to be located in several cellular components, including bounding membrane of organelle; condensed chromosome; and microtubule cytoskeleton. Predicted to be part of ESCRT III complex and nuclear pore. Predicted to be active in multivesicular body. Is expressed in brain and migrating neural crest. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 8. Orthologous to human CHMP1A (charged multivesicular body protein 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chmp1a |
| Official Name | charged multivesicular body protein 1A [Source:MGI Symbol;Acc:MGI:1920159] |
| Ensembl ID | ENSMUSG00000000743 |
| Bio databases IDs | |
| Aliases | charged multivesicular body protein 1A |
| Synonyms | 2900018H07Rik, charged multivesicular body protein 1A, CHMP1, METALLOPEPTIDASE 1, PCH8, PCOLN3, PRSM1, VPS46-1, VPS46A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chmp1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- metallopeptidase
- zinc ion binding
- peptidase
- protein homodimerization
- protein domain specific binding
- protein binding
- identical protein binding
- Snf7
Pathways
Biological processes and signaling networks where the Chmp1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- pontocerebellar hypoplasia type 8
- sunburn
- schizophrenia
- osteoarthritis
- epithelial basal cell carcinoma
- hereditary disorder
- nicotine dependence
- non-syndromic congenital pontocerebellar hypoplasia
role in cell
- growth
- production in
- quantity
- fusion
- assembly
- organization
- autophagy by
- duplication
- ferroptosis
- distribution in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endomembrane system
- Cytoplasm
- perinuclear region
- Nucleus
- Plasma Membrane
- centrosome
- midbody
- microtubule organizing centers
- cytosol
- lysosome membrane
- endosomal membrane
- chromosome
- nuclear pores
- nucleoplasm
- nuclear scaffolds
- nuclear matrix
- autophagic vacuoles
- early endosomes
- multivesicular bodies
- kinetochore microtubule
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chmp1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- mitotic chromosome condensation
- protein transport
- late endosome to vacuole transport
- nucleus organization
- cell division
- negative regulation of gene expression
- vesicle-mediated transport
- non-lytic virus budding from plasma membrane
- regulation of centrosome duplication
- plasma membrane repair
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- autophagy
- endosome transport via multivesicular body sorting pathway
- multivesicular body sorting pathway
- nuclear envelope reassembly
- mitotic metaphase plate congression
- vesicle fusion with vacuole
Cellular Component
Where in the cell the gene product is active
- ESCRT III complex
- multivesicular body
- kinetochore
- plasma membrane
- autophagic vacuole membrane
- lysosomal membrane
- nuclear pore
- condensed nuclear chromosome
- early endosome
- extracellular vesicular exosome
- microtubule organizing center
- kinetochore microtubule
- endomembrane system
- cytosol
- nuclear matrix
- multivesicular body membrane
- midbody
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- identical protein binding
- protein domain specific binding
- protein binding
- protein homodimerization activity
- metallopeptidase activity