Nup214 Gene Summary [Mouse]
A structural constituent of nuclear pore. Acts upstream of or within mRNA export from nucleus; protein import into nucleus; and regulation of cell cycle. Predicted to be located in nuclear envelope. Predicted to be part of nuclear pore. Is expressed in future spinal cord; lung; and nervous system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; and brain disease. Orthologous to human NUP214 (nucleoporin 214). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nup214 |
| Official Name | nucleoporin 214 [Source:MGI Symbol;Acc:MGI:1095411] |
| Ensembl ID | ENSMUSG00000001855 |
| Bio databases IDs | |
| Aliases | nucleoporin 214 |
| Synonyms | BC039282, CAIN, CAN, D2H9S46E, IIAE9, MGC37347, nucleoporin 214, NUP200, RGD1304977 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nup214 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FG repeat
- Crm1 binding domain
- Family of unknown function (DUF5585)
- structural constituent of nuclear pore
- protein binding
- Keratin type II head
- nuclear localization sequence binding
- Nucleoporin Nup214 phenylalanine-glycine (FG) domain
- nuclear export signal receptor
- transporter
Pathways
Biological processes and signaling networks where the Nup214 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- susceptibility to acute infection induced encephalopathy type 9
- renal cell carcinoma
- acute myeloid leukemia
- renal cell cancer
- nodular sclerosis classical Hodgkin lymphoma
- nodular sclerosis Hodgkin disease
- focal cortical dysplasia of Taylor
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
role in cell
- proliferation
- cell death
- replication in
- expansion
- depletion
- cell cycle progression
- regulation
- regulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- cytosol
- nuclear pores
- nucleoplasm
- nuclear rim
- nuclear envelope
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nup214 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- nucleocytoplasmic transport
- RNA export from nucleus
- protein import into nucleus
- regulation of cell cycle
- protein export from nucleus
- regulation of nucleocytoplasmic transport
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- cytosol
- nucleoplasm
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of nuclear pore
- nuclear localization sequence binding
- nuclear export signal receptor activity