Rpl3l Gene Summary [Mouse]

A structural constituent of ribosome. Involved in negative regulation of myotube differentiation and regulation of striated muscle tissue development. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2D. Orthologous to human RPL3L (ribosomal protein L3 like). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Rpl3l
Official Name
ribosomal protein L3-like [Source:MGI Symbol;Acc:MGI:1913461]
Ensembl ID
ENSMUSG00000002500
Bio databases IDs NCBI: 66211 Ensembl: ENSMUSG00000002500
Aliases ribosomal protein L3-like
Synonyms 1110057H16Rik, CMD2D, RIBOSOMAL protein L3-LIKE
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl3l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Ribosomal protein L3
  • structural constituent of ribosome
  • rpl3p
  • RNA binding

Pathways

Biological processes and signaling networks where the Rpl3l gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • dilated cardiomyopathy type 2D
  • atrial fibrillation
  • cardioembolic stroke
role in cell
  • differentiation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • ribosome

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl3l gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of myotube differentiation
  • regulation of striated muscle tissue development
  • translation

Cellular Component

Where in the cell the gene product is active
  • membrane
  • cytosolic large ribosomal subunit
  • ribosome

Molecular Function

What the gene product does at the molecular level
  • RNA binding
  • structural constituent of ribosome

Gene-Specific Assays for Results You Can Trust

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