Ikzf4 Gene Summary [Mouse]
Enables bHLH transcription factor binding activity and sequence-specific DNA binding activity. Acts upstream of or within negative regulation of DNA-templated transcription and positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body. Predicted to be part of protein-containing complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; hemolymphoid system; and retina. Used to study encephalomyelitis. Orthologous to human IKZF4 (IKAROS family zinc finger 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ikzf4 |
| Official Name | IKAROS family zinc finger 4 [Source:MGI Symbol;Acc:MGI:1343139] |
| Ensembl ID | ENSMUSG00000002578 |
| Bio databases IDs | |
| Aliases | IKAROS family zinc finger 4 |
| Synonyms | A630026H08Rik, EOS, IKAROS family zinc finger 4, Zfpn1a4, ZNFN1A4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ikzf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- zinc ion binding
- Zinc-finger double domain
- C2H2-type zinc-finger domain
- transcription factor binding
- protein domain specific binding
- protein binding
- zinc finger domain
- sequence-specific DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- vitiligo
- Alzheimer disease
- asthma
- Crohn disease
- insulin-dependent diabetes mellitus
- alopecia areata
- Down syndrome
role in cell
- expression in
- proliferation
- quantity
- differentiation
- production in
- development
- tyrosine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ikzf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- protein homooligomerization
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein domain specific binding
- zinc ion binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- bHLH transcription factor binding