Matk Gene Summary [Mouse]
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be located in cytoplasm and membrane. Predicted to be active in plasma membrane. Is expressed in brain; gonad; hemolymphoid system gland; and intestine. Orthologous to human MATK (megakaryocyte-associated tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Matk |
| Official Name | megakaryocyte-associated tyrosine kinase [Source:MGI Symbol;Acc:MGI:99259] |
| Ensembl ID | ENSMUSG00000004933 |
| Bio databases IDs | |
| Aliases | megakaryocyte-associated tyrosine kinase |
| Synonyms | Batk, CHK, CTK, HHYLTK, HYL, HYLTK, Lsk, megakaryocyte-associated tyrosine kinase, Ntk, p56ntk |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Matk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP-binding domain
- Src homology 2 (SH2) domain
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- Tyrosine kinase, catalytic domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Matk gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- cutaneous melanoma
- cutaneous melanoma cancer
- insulin resistance
- tumorigenesis
- primary Sjögren syndrome
role in cell
- expression in
- formation
- quantity
- proliferation
- activation in
- number
- outgrowth
- phosphorylation in
- growth
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- membrane fraction
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Matk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity