Efna2 Gene Summary [Mouse]
Enables ephrin receptor binding activity. Involved in bone remodeling; ephrin receptor signaling pathway; and osteoclast differentiation. Predicted to be located in neuromuscular junction and perikaryon. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and limb. Orthologous to human EFNA2 (ephrin A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Efna2 |
| Official Name | ephrin A2 [Source:MGI Symbol;Acc:MGI:102707] |
| Ensembl ID | ENSMUSG00000003070 |
| Bio databases IDs | |
| Aliases | ephrin A2 |
| Synonyms | CEK7L, ELF-1, ephrin A2, EPHRIN A6, Epl6, EPLG6, HEK7-L, HEK7-ligand, LERK-6, LOC100506781 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Efna2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- receptor binding domain
- Ephrin
- Cupredoxin superfamily
- ephrin receptor binding
- protein binding
- membrane-proximal domain
Pathways
Biological processes and signaling networks where the Efna2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- soft tissue sarcoma cancer
- synovial sarcoma
role in cell
- survival
- expression in
- cell viability
- differentiation
- binding
- development
- motility
- collapse
- innervation
- induction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- Cytoplasm
- cellular membrane
- neuromuscular junctions
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Efna2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osteoclast differentiation
- bone remodeling
- ephrin receptor signaling pathway
- cell-cell signaling
- axon guidance
- olfactory bulb development
Cellular Component
Where in the cell the gene product is active
- neuromuscular junction
- perikaryon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ephrin receptor binding