Zbtb46 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of leukocyte activation and regulation of leukocyte differentiation. Located in chromatin. Is expressed in several structures, including brown fat; central nervous system; gonad; renal vasculature; and spleen. Orthologous to human ZBTB46 (zinc finger and BTB domain containing 46). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zbtb46 |
| Official Name | zinc finger and BTB domain containing 46 [Source:MGI Symbol;Acc:MGI:1919397] |
| Ensembl ID | ENSMUSG00000027583 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 46 |
| Synonyms | 2610019F01RIK, 4933406L05Rik, BTBD4, BZEL, dJ583P15.7, dJ583P15.8, LOC103691997, RINZF, zinc finger and BTB domain containing 46, ZNF340 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zbtb46 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- nucleic acid binding
- C2H2-type zinc-finger domain
- BTB_POZ
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- Broad-Complex, Tramtrack and Bric a brac
- double-stranded DNA binding
- Zinc-finger double domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- SANT and BTB domain regulator of CSR, BTB domain
- BTB/POZ domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- chronic osteomyelitis
- prostate cancer
- epithelial cancer
- cancer
- abdominal aortic aneurysm
- kidney carcinoma
- renal cancer
- prostatic carcinoma
role in cell
- expression in
- production in
- differentiation
- quantity
- activation
- differentiation by
- number
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell surface
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zbtb46 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of macrophage differentiation
- plasmacytoid dendritic cell differentiation
- negative regulation of dendritic cell differentiation
- granulocyte differentiation
- positive regulation of dendritic cell differentiation
- negative regulation of granulocyte differentiation
- negative regulation of monocyte differentiation
- negative regulation of leukocyte activation
- macrophage differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity