Limk2 Gene Summary [Mouse]
Enables protein kinase activity. Acts upstream of or within several processes, including cornea development in camera-type eye; protein phosphorylation; and spermatogenesis. Located in cis-Golgi network and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human LIMK2 (LIM domain kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Limk2 |
| Official Name | LIM motif-containing protein kinase 2 [Source:MGI Symbol;Acc:MGI:1197517] |
| Ensembl ID | ENSMUSG00000020451 |
| Bio databases IDs | |
| Aliases | LIM motif-containing protein kinase 2 |
| Synonyms | A930024P04RIK, LIM domain kinase 2, Limk2b, Link2, whe |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Limk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PKC-activated protein phosphatase-1 inhibitor
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- canonical PDZ domain
- protein binding
- Protein kinase domain
- PDZ domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Limk2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Axonal Guidance Signaling
- CCR3 Signaling in Eosinophils
- Cdc42 Signaling
- Chemokine Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- Estrogen Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- IL-8 Signaling
- Natural Killer Cell Signaling
- PAK Signaling
- Phagosome Formation
- Rac Signaling
- RhoA Signaling
- RhoGDI Signaling
- Role of Tissue Factor in Cancer
- Semaphorin Signaling in Neurons
- Signaling by Rho Family GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic lung adenocarcinoma
- metastatic non-small cell lung cancer
- metastatic non-squamous non-small cell lung cancer
- advanced non-small cell lung cancer
- metastatic large cell lung carcinoma
- advanced lung squamous cell carcinoma
- stage IV lung squamous cell carcinoma
- advanced non-small cell lung adenocarcinoma
- advanced large cell lung carcinoma
- squamous cell lung cancer
role in cell
- phosphorylation in
- differentiation
- degradation in
- cell viability
- apoptosis
- migration
- invasion
- survival
- formation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- cytosol
- cis Golgi networks
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Limk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein localization to nucleus
- astral microtubule organization
- head development
- establishment of vesicle localization
- spermatogenesis
- positive regulation of protein phosphorylation
- phosphorylation
- protein phosphorylation
- actin cytoskeleton organization
- cornea development in camera-type eye
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cis-Golgi network
- perinuclear region of cytoplasm
- mitotic spindle
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein serine/threonine kinase activity