Il12rb2 Gene Summary [Mouse]
Enables protein kinase binding activity. Acts upstream of or within peptidyl-tyrosine phosphorylation; response to cytokine; and response to lipopolysaccharide. Located in external side of plasma membrane. Is expressed in several structures, including brain ventricular layer; genitourinary system; incisor; olfactory epithelium; and submandibular gland. Orthologous to human IL12RB2 (interleukin 12 receptor subunit beta 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il12rb2 |
| Official Name | interleukin 12 receptor, beta 2 [Source:MGI Symbol;Acc:MGI:1270861] |
| Ensembl ID | ENSMUSG00000018341 |
| Bio databases IDs | |
| Aliases | interleukin 12 receptor, beta 2 |
| Synonyms | A930027I18RIK, Ifnm, IL12R beta2, interleukin 12 receptor, beta 2, interleukin 12 receptor subunit beta 2, interleukin 12 receptor subunit β 2, interleukin 12 receptor, β 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il12rb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ig-like C2-type domain
- protein kinase binding
- cytoplasmic domain
- FN3
- transmembrane domain
- protein binding
- Fibronectin type 3 domain
- cytokine receptor
- transmembrane receptor
- coreceptor
Pathways
Biological processes and signaling networks where the Il12rb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- infection
- COVID-19
- rheumatoid arthritis
- systemic lupus erythematosus
- Alzheimer disease
- primary biliary cirrhosis
- systemic sclerosis
- tic disorder
- stuttering
role in cell
- production in
- activation in
- expression in
- binding in
- differentiation
- proliferation
- quantity
- response
- activation
- polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il12rb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytokine-mediated signaling pathway
- positive regulation of cell proliferation
- positive regulation of interferon-gamma production
- cell surface receptor signaling pathway
- response to lipopolysaccharide
- interleukin-12-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- coreceptor activity
- cytokine receptor activity
- cytokine binding