Ebi3 Gene Summary [Mouse]
Enables interleukin-27 receptor binding activity. Involved in T cell proliferation. Predicted to be located in extracellular space and membrane. Is expressed in several structures, including decidua; extraembryonic component; sensory organ; and skeleton. Orthologous to human EBI3 (Epstein-Barr virus induced 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ebi3 |
| Official Name | Epstein-Barr virus induced gene 3 [Source:MGI Symbol;Acc:MGI:1354171] |
| Ensembl ID | ENSMUSG00000003206 |
| Bio databases IDs | |
| Aliases | Epstein-Barr virus induced gene 3 |
| Synonyms | Epstein-Barr virus induced 3, Epstein-Barr virus induced gene 3, IL-27, IL-27B, IL35B, LOC682552 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ebi3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-27 receptor binding
- FN3
- protein binding
- Fibronectin type 3 domain
- cytokine
Pathways
Biological processes and signaling networks where the Ebi3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- insulin resistance
- diabetes mellitus
- fibrosis
- insulin-dependent diabetes mellitus
- cancer
- epithelial neoplasia
- epithelial cancer
- digestive system cancer
role in cell
- production in
- expression in
- proliferation
- phosphorylation in
- activation in
- induction in
- number
- quantity
- growth
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Plasma Membrane
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ebi3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of alpha-beta T cell proliferation
- cytokine-mediated signaling pathway
- T cell proliferation
- positive regulation of interferon-gamma production
- humoral immune response
- T-helper 1 type immune response
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- external side of plasma membrane
- receptor complex
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- interleukin-27 receptor binding
- cytokine activity
- cytokine binding
- cytokine receptor activity