CDKL3 Gene Summary [Human]
The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | CDKL3 |
| Official Name | cyclin dependent kinase like 3 [Source:HGNC Symbol;Acc:HGNC:15483] |
| Ensembl ID | ENSG00000006837 |
| Bio databases IDs | |
| Aliases | cyclin dependent kinase like 3, serine-threonine protein kinase NKIAMRE |
| Synonyms | AI852479, B230379H01Rik, cyclin-dependent kinase-like 3, LOC103693326, LOC103694901, NKIAMRE, Nkiatre, NKIATREB |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDKL3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- leukemia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- spontaneous preterm birth
role in cell
- expression in
- colony formation by
- morphogenesis
- growth
- survival
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDKL3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- negative regulation of axon extension
- regulation of cell cycle
- protein phosphorylation
- positive regulation of dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- cyclin-dependent protein kinase activity
- protein serine/threonine kinase activity