Ogdh Gene Summary [Mouse]
Enables oxoglutarate dehydrogenase (NAD+) activity. Involved in brain development. Located in mitochondrion. Part of oxoglutarate dehydrogenase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in oxoglutarate dehydrogenase deficiency. Orthologous to human OGDH (oxoglutarate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ogdh |
| Official Name | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) [Source:MGI Symbol;Acc:MGI:1098267] |
| Ensembl ID | ENSMUSG00000020456 |
| Bio databases IDs | |
| Aliases | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) |
| Synonyms | 2210403E04RIK, 2210412K19Rik, AKGDH, Alpha-ketoglutarate dehydrogenase, d1401, E1k, E1o, HsOGDH, Kdh E1, KGD1, KGDH, LOC103693780, mKIAA4192, ODO1, OGDC, OGDH2, OGDHD, OGDH-E1, oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide), oxoglutarate dehydrogenase, oxoglutarate (α-ketoglutarate) dehydrogenase (lipoamide), α-ketoglutarate dehydrogenase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ogdh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 2-oxoglutarate dehydrogenase C-terminal
- vitamin binding
- 2-oxoglutarate dehydrogenase N-terminus
- 2-oxoglutarate dehydrogenase, E1 component
- Transketolase, pyrimidine binding domain
- TPP_enzymes
- oxoglutarate dehydrogenase (lipoamide)
- heat shock protein binding
- Dehydrogenase E1 component
- enzyme
- protein binding
- binding protein
- chaperone binding
- thiamine pyrophosphate-dependent enzyme pyrimidine binding domain
- kgd
- aldehyde or oxo group:NAD or NADP oxidoreductase
Pathways
Biological processes and signaling networks where the Ogdh gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- organismal death
- alpha-ketoglutarate dehydrogenase deficiency
- hepatocellular carcinoma
- liver cancer
- Alzheimer disease
- colorectal cancer
role in cell
- expression in
- proliferation
- phosphorylation in
- migration
- invasion by
- cytolysis
- permeability transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Mitochondria
- mitochondrial membrane
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ogdh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- olfactory bulb mitral cell layer development
- generation of precursor metabolites and energy
- glycolysis
- tangential migration from the subventricular zone to the olfactory bulb
- hippocampus development
- tricarboxylic acid cycle
- striatum development
- cerebellar cortex development
- thalamus development
- pyramidal neuron development
- 2-oxoglutarate metabolic process
- succinyl-CoA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial membrane
- mitochondrial matrix
- oxoglutarate dehydrogenase complex
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- thiamine pyrophosphate binding
- protein binding
- metal ion binding
- oxoglutarate dehydrogenase (succinyl-transferring) activity
- oxoglutarate dehydrogenase (NAD+) activity