Cbll1 Gene Summary [Mouse]
Enables identical protein binding activity and ubiquitin protein ligase activity. Acts upstream of or within negative regulation of cell adhesion; positive regulation of cell migration; and positive regulation of endocytosis. Located in cytoplasm and nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in heart ventricle. Orthologous to several human genes including CBLL1 (Cbl proto-oncogene like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cbll1 |
| Official Name | Casitas B-lineage lymphoma-like 1 [Source:MGI Symbol;Acc:MGI:2144842] |
| Ensembl ID | ENSMUSG00000020659 |
| Bio databases IDs | |
| Aliases | Casitas B-lineage lymphoma-like 1 |
| Synonyms | Casitas B-lineage lymphoma-like 1, Cbl proto-oncogene like 1, c-Cbl-like, HAKAI, RNF188 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cbll1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C2H2 Hakai zinc finger domain
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- enzyme
- protein binding
- identical protein binding
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Cbll1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- colon cancer
- gastric cancer
- melanoma
- melanoma cancer
role in cell
- expression in
- replication in
- motility
- proliferation
- endocytosis by
- adhesion
- migration
- degradation in
- binding in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- endosomes
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cbll1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell adhesion
- positive regulation of endocytosis
- regulation of cell adhesion
- mRNA processing
- protein ubiquitination
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
- nuclear speck
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- identical protein binding
- protein binding
- metal ion binding