Dffa Gene Summary [Mouse]
Predicted to enable deoxyribonuclease inhibitor activity; protein domain specific binding activity; and protein folding chaperone. Acts upstream of or within negative regulation of apoptotic DNA fragmentation; positive regulation of apoptotic process; and thymocyte apoptotic process. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in chromatin. Is expressed in several structures, including brain; heart; hemolymphoid system gland; liver; and metanephros. Orthologous to human DFFA (DNA fragmentation factor subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dffa |
| Official Name | DNA fragmentation factor, alpha subunit [Source:MGI Symbol;Acc:MGI:1196227] |
| Ensembl ID | ENSMUSG00000028974 |
| Bio databases IDs | |
| Aliases | DNA fragmentation factor, alpha subunit |
| Synonyms | A330085O09Rik, DFF1, DFF35, DFF-45, DNA fragmentation factor, alpha subunit, DNA fragmentation factor subunit alpha, DNA fragmentation factor subunit α, DNA fragmentation factor, α subunit, ICAD, ICAD-S |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dffa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- caspase recognition motif
- Caspase 3 cleavage site
- CIDE-N domain
- caspase cleavage site
- enzyme inhibitor activity
- nuclear localization sequence
- CIDE_N
- protein domain specific binding
- enzyme
- protein binding
- ESGE motif
- DNA Fragmentation factor 45kDa, C terminal domain
Pathways
Biological processes and signaling networks where the Dffa gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colon adenocarcinoma
- colon epithelial cancer
- major depression
- chromosomal instability
role in cell
- apoptosis
- activation in
- cell death
- transmembrane potential
- condensation
- fragmentation in
- laddering in
- excitotoxicity
- internucleosomal DNA fragmentation in
- tumorigenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dffa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of deoxyribonuclease activity
- apoptotic DNA fragmentation
- positive regulation of apoptotic process
- thymocyte apoptotic process
- chaperone-mediated protein folding
- negative regulation of execution phase of apoptosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- macromolecular complex
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- protein binding involved in protein folding
- deoxyribonuclease inhibitor activity