Rhot1 Gene Summary [Mouse]
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including establishment of mitochondrion localization, microtubule-mediated; mitochondrial outer membrane permeabilization; and regulation of organelle transport along microtubule. Located in mitochondrion. Is expressed in brain and head. Used to study motor neuron disease. Orthologous to human RHOT1 (ras homolog family member T1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rhot1 |
| Official Name | ras homolog family member T1 [Source:MGI Symbol;Acc:MGI:1926078] |
| Ensembl ID | ENSMUSG00000017686 |
| Bio databases IDs | |
| Aliases | ras homolog family member T1 |
| Synonyms | 2210403N23Rik, ARHT1, C430039G08RIK, MIRO, MIRO-1, ras homolog family member T1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rhot1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- small GTP-binding protein domain
- EF hand associated
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- Rab subfamily of small GTPases
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Pathways
Biological processes and signaling networks where the Rhot1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- Gαq Signaling
- HMGB1 Signaling
- IL-8 Signaling
- ILK Signaling
- Integrin Signaling
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of Actin-based Motility by Rho
- RhoGDI Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Sphingosine-1-phosphate Signaling
- Tec Kinase Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- cyanosis
- gout
- pancreatic cancer
- respiratory failure
- cataract
- idiopathic scoliosis
role in cell
- expression in
- binding in
- accumulation in
- binding
- apoptosis
- accumulation
- number
- ferroptosis
- abnormal morphology
- budding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial outer membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rhot1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular homeostasis
- small GTPase mediated signal transduction
- mitochondrion transport along microtubule
- regulation of mitochondrion organization
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- membrane
- mitochondrion
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- calcium ion binding