Nckap1l Gene Summary [Mouse]
Predicted to enable GTPase activator activity; TORC2 complex binding activity; and protein kinase activator activity. Involved in several processes, including lymphocyte homeostasis; negative regulation of cytokine production; and positive regulation of lymphocyte activation. Part of SCAR complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and musculature. Human ortholog(s) of this gene implicated in immunodeficiency 72. Orthologous to human NCKAP1L (NCK associated protein 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Nckap1l |
| Official Name | NCK associated protein 1 like [Source:MGI Symbol;Acc:MGI:1926063] |
| Ensembl ID | ENSMUSG00000022488 |
| Bio databases IDs | |
| Aliases | NCK associated protein 1 like |
| Synonyms | 4930568P13Rik, HEM1, Hemp1, IMD72, NCK associated protein 1 like |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nckap1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- Nck-associated protein 1
- binding protein
- GTPase activator
- protein binding
Pathways
Biological processes and signaling networks where the Nckap1l gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- sphingosine-1-phosphate
- cuprizone
- CpG ODN 2006
- siponimod
- resiquimod
- LMK-235
- PLX5622
- TYROBP
disease
- diabetic nephropathy
- periodontitis
- immunodeficiency 72 with autoinflammation
- androgenic alopecia
- estrogen receptor positive breast cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
phenotypes
- abnormal CD4-positive T cell differentiation
- abnormal common myeloid progenitor cell morphology
- abnormal epididymis morphology
- abnormal erythroid progenitor cell morphology
- abnormal immune system organ morphology
- abnormal liver morphology
- abnormal lymphopoiesis
- abnormal regulatory T cell number
- abnormal renal glomerulus morphology
- abnormal thoracic cavity morphology
- abnormal thymus lobule morphology
- acanthocytosis
- amyloidosis
- cardiac fibrosis
- dacryocytosis
- decreased B cell number
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased CD8-positive naive alpha-beta T cell number
- decreased NK cell number
- decreased T cell proliferation
- decreased alpha-beta T cell number
- decreased body weight
- decreased central memory CD8 positive alpha-beta T cell number
- decreased double-positive T cell number
- decreased hematocrit
- decreased lymphocyte cell number
- decreased mature B cell number
- decreased mature gamma-delta T cell number
- decreased mean corpuscular volume
- extramedullary hematopoiesis
- heart inflammation
- hypochromic microcytic anemia
- impaired macrophage phagocytosis
- impaired neutrophil chemotaxis
- impaired neutrophil phagocytosis
- increased CD8-positive alpha-beta T cell number
- increased alpha-beta T cell number
- increased circulating interleukin-17 level
- increased circulating interleukin-6 level
- increased double-negative T cell number
- increased effector memory CD4-positive alpha-beta T cell number
- increased effector memory CD8-positive alpha-beta T cell number
- increased erythrocyte osmotic fragility
- increased interleukin-17 secretion
- increased interleukin-6 secretion
- increased leukocyte cell number
- increased neutrophil cell number
- increased tumor necrosis factor secretion
- liver inflammation
- lung inflammation
- lymph node hypoplasia
- poikilocytosis
- reticulocytosis
- schistocytosis
- spleen hyperplasia
- thymus hypoplasia
role in cell
- apoptosis
- expression in
- proliferation
- phosphorylation in
- activation in
- migration
- chemotaxis
- differentiation
- formation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- secretory granule membrane
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nckap1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of phagocytosis, engulfment
- cell projection assembly
- neuron projection morphogenesis
- positive regulation of lymphocyte differentiation
- positive regulation of gamma-delta T cell differentiation
- myeloid cell homeostasis
- response to xenobiotic stimulus
- positive regulation of erythrocyte differentiation
- T cell homeostasis
- cortical actin cytoskeleton organization
- chemotaxis
- positive regulation of CD4-positive, alpha-beta T cell differentiation
- positive regulation of cell adhesion mediated by integrin
- negative regulation of interleukin-17 production
- cell migration
- B cell receptor signaling pathway
- negative regulation of cytotoxic T cell degranulation
- positive regulation of phosphorylation
- macromolecular complex assembly
- erythrocyte homeostasis
- positive regulation of neutrophil chemotaxis
- cell morphogenesis
- positive regulation of CD8-positive, alpha-beta T cell differentiation
- erythrocyte development
- positive regulation of T cell proliferation
- B cell homeostasis
- positive regulation of B cell differentiation
- negative regulation of interleukin-6 production
- positive regulation of leukocyte migration
- negative regulation of myosin-light-chain-phosphatase activity
- negative regulation of apoptotic process
- positive regulation of actin filament polymerization
- maintenance of cell polarity
- neutrophil chemotaxis
- actin polymerization-dependent cell motility
- positive regulation of B cell proliferation
Cellular Component
Where in the cell the gene product is active
- SCAR complex
- secretory granule membrane
- extracellular vesicular exosome
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein kinase activator activity
- GTPase activator activity