Npff Gene Summary [Mouse]
This gene encodes neuropeptides involved in analgesia, cardiovascular regulation, neuroendocrine function and opiate addiction. The encoded protein is a preproprotein that undergoes further processing to generate multiple amidated peptides. [provided by RefSeq, Jul 2015]
Details
| Type | Protein Coding |
| Official Symbol | Npff |
| Official Name | neuropeptide FF-amide peptide precursor [Source:MGI Symbol;Acc:MGI:1891708] |
| Ensembl ID | ENSMUSG00000023052 |
| Bio databases IDs | |
| Aliases | neuropeptide FF-amide peptide precursor |
| Synonyms | FMRFAL, neuropeptide FF-amide peptide precursor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Npff often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- receptor agonist activity
- protein binding
- receptor binding
- neuropeptide hormone
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- repetitive behavior
- sneeze
role in cell
- activation
- production
- hyperexcitability
- elevation in
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- vesicles
- secretory granules
- perikaryon
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Npff gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- neuropeptide signaling pathway
- synaptic transmission
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular space
- perikaryon
- extracellular region
- axon terminus
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- neuropeptide hormone activity
- receptor binding