Rcl1 Gene Summary [Mouse]
Predicted to enable RNA endonuclease activity. Acts upstream of or within endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Is expressed in several structures, including axial musculature; cerebral cortex; gut; liver lobe; and submandibular gland primordium. Orthologous to human RCL1 (RNA terminal phosphate cyclase like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rcl1 |
| Official Name | RNA terminal phosphate cyclase-like 1 [Source:MGI Symbol;Acc:MGI:1913275] |
| Ensembl ID | ENSMUSG00000024785 |
| Bio databases IDs | |
| Aliases | RNA terminal phosphate cyclase-like 1 |
| Synonyms | 2310040A02Rik, Ab1-353, Ac1292, RNAC, RNA terminal phosphate cyclase-like 1, RPCL1, RTC2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rcl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 18S rRNA biogenesis protein RCL1
- RNA 3'-terminal phosphate cyclase
- RNA 3'-phosphate cyclase
- enzyme
- protein binding
- RNA 3'-terminal phosphate cyclase (RTC), insert domain
- EPT_RTPC-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thrombocytopenia
- acute myeloid leukemia
- androgenic alopecia
- psychosis
role in cell
- growth
- processing in
- CSN5i-3 sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pre-ribosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rcl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- ribosomal small subunit biogenesis
- endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- endoribonuclease activity