Ddx4 Gene Summary [Mouse]
Enables ATP hydrolysis activity. Involved in male meiosis I; regulatory ncRNA-mediated gene silencing; and spermatogenesis. Acts upstream of with a positive effect on transposable element silencing by piRNA-mediated heterochromatin formation. Acts upstream of or within regulation of protein localization. Located in cytoplasmic ribonucleoprotein granule; nucleus; and perinuclear region of cytoplasm. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system mesentery; aorta-gonad-mesonephros; embryo ectoderm; gonad; and gonad primordium. Orthologous to human DDX4 (DEAD-box helicase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddx4 |
| Official Name | DEAD box helicase 4 [Source:MGI Symbol;Acc:MGI:102670] |
| Ensembl ID | ENSMUSG00000021758 |
| Bio databases IDs | |
| Aliases | DEAD box helicase 4 |
| Synonyms | Dbx4, DEAD-box helicase 4, Mvh, RVLG, VASA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddx4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- protein binding activity, bridging
- enzyme
- protein binding
- Helicase conserved C-terminal domain
- ATPase
- ATPase domain
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- RNA-binding domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- familial colorectal cancer
- organismal death
- diabetic nephropathy
role in cell
- cell death
- expression in
- proliferation
- differentiation
- motility
- cisplatin sensitivity
- production
- meiosis I
- meiosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- perinuclear region
- cytosol
- sister chromatids
- perinuclear space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddx4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- sperm motility
- spermatogenesis
- male meiosis
- male meiosis I
- cell differentiation
- piRNA metabolic process
- gamete generation
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- P granule
- pi-body
- piP-body
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA helicase activity
- mRNA binding