Mael Gene Summary [Mouse]
Predicted to enable sequence-specific DNA binding activity. Involved in piRNA processing and transposable element silencing by piRNA-mediated DNA methylation. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; meiotic nuclear division; and negative regulation of macromolecule biosynthetic process. Located in several cellular components, including chromosome; cytoplasmic ribonucleoprotein granule; and male germ cell nucleus. Is expressed in brain; early conceptus; and genitourinary system. Orthologous to human MAEL (maelstrom spermatogenic transposon silencer). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mael |
| Official Name | maelstrom spermatogenic transposon silencer [Source:MGI Symbol;Acc:MGI:2138453] |
| Ensembl ID | ENSMUSG00000040629 |
| Bio databases IDs | |
| Aliases | maelstrom spermatogenic transposon silencer |
| Synonyms | 4933405K18Rik, CT128, Maelstrom, maelstrom spermatogenic transposon silencer, RGD1309333, SPATA35 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mael often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- piRNA pathway germ-plasm component
- high mobility group (HMG)-box domain superfamily
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- epithelial cancer
- organismal death
- astigmatism
- hepatocellular carcinoma
- liver cancer
- male infertility
- insomnia
role in cell
- expression in
- quantity
- apoptosis
- cell viability
- proliferation
- phosphorylation in
- migration
- invasion by
- meiosis
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- autosome
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- perinuclear region
- cytosol
- sister chromatids
- nucleoplasm
- sex chromatin
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mael gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell programmed cell death
- cell morphogenesis
- male meiosis
- spermatogenesis
- fertilization
- regulation of organ growth
- DNA damage response, signal transduction resulting in induction of apoptosis
- negative regulation of developmental process
- synapsis
- regulation of gene silencing by miRNA
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
- gene silencing by RNA
- piRNA metabolic process
- negative regulation of reproductive process
- genetic imprinting
Cellular Component
Where in the cell the gene product is active
- XY body
- nucleus
- chromatoid body
- perinuclear region of cytoplasm
- cytoplasm
- P granule
- autosome
- chromatin
- piP-body
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding