Tdrd1 Gene Summary [Mouse]
Predicted to enable zinc ion binding activity. Involved in germ cell development; regulatory ncRNA-mediated gene silencing; and spermatogenesis. Located in chromatoid body and pi-body. Part of ribonucleoprotein complex. Is active in synapse. Is expressed in several structures, including reproductive system. Orthologous to human TDRD1 (tudor domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tdrd1 |
| Official Name | tudor domain containing 1 [Source:MGI Symbol;Acc:MGI:1933218] |
| Ensembl ID | ENSMUSG00000025081 |
| Bio databases IDs | |
| Aliases | tudor domain containing 1 |
| Synonyms | CT41.1, MTR-1, tudor domain containing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tdrd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tudor domain
- MYND finger
- protein binding
- Tudor domain superfamily
- extended Tudor domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- idiopathic scoliosis
- insomnia
- azoospermia
- male infertility
role in cell
- proliferation
- apoptosis
- formation
- formation in
- abnormal morphology
- interaction in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- cytosol
- sister chromatids
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tdrd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- meiotic cell cycle
- spermatogenesis
- P granule organization
- piRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- chromatoid body
- cytoplasm
- P granule
- pi-body
- synapse
Molecular Function
What the gene product does at the molecular level
- metal ion binding