Chmp6 Gene Summary [Mouse]
Predicted to be involved in several processes, including midbody abscission; regulation of protein metabolic process; and vacuolar transport. Predicted to be located in several cellular components, including bounding membrane of organelle; kinetochore microtubule; and midbody. Predicted to be part of ESCRT III complex and nuclear pore. Predicted to be active in multivesicular body. Is expressed in several structures, including branchial arch; facial prominence; heart; limb bud; and neural fold. Orthologous to human CHMP6 (charged multivesicular body protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chmp6 |
| Official Name | charged multivesicular body protein 6 [Source:MGI Symbol;Acc:MGI:3583942] |
| Ensembl ID | ENSMUSG00000025371 |
| Bio databases IDs | |
| Aliases | charged multivesicular body protein 6 |
| Synonyms | 2400004G01Rik, charged multivesicular body protein 6, RGD1565325, VPS20 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chmp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- PTZ00464
- protein binding
- Snf7
Pathways
Biological processes and signaling networks where the Chmp6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
regulated by
- BAG3
- TYA-018
role in cell
- cell death
- damage
- abscission
- fusion
- organization
- autophagy by
- assembly
- macroautophagy in
- aggregation in
- downregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- midbody
- cytosol
- lysosome membrane
- endosomal membrane
- nuclear pores
- autophagic vacuoles
- multivesicular bodies
- kinetochore microtubule
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chmp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- negative regulation of epidermal growth factor-activated receptor activity
- protein transport
- regulation of protein catabolic process
- nucleus organization
- membrane budding
- non-lytic virus budding from plasma membrane
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- plasma membrane repair
- autophagy
- multivesicular body sorting pathway
- nuclear envelope reassembly
- mitotic metaphase plate congression
- late endosome to vacuole transport via multivesicular body sorting pathway
- macroautophagy
- vesicle fusion with vacuole
Cellular Component
Where in the cell the gene product is active
- ESCRT III complex
- kinetochore
- multivesicular body
- plasma membrane
- lysosomal membrane
- autophagic vacuole membrane
- nuclear pore
- extracellular vesicular exosome
- kinetochore microtubule
- membrane
- cytosol
- endosome membrane
- multivesicular body membrane
- midbody
Molecular Function
What the gene product does at the molecular level
- protein binding