Adcy2 Gene Summary [Mouse]

Enables adenylate cyclase binding activity. Predicted to be involved in several processes, including cAMP biosynthetic process; cAMP-mediated signaling; and cellular response to forskolin. Predicted to act upstream of or within activation of adenylate cyclase activity. Located in dendrite and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ADCY2 (adenylate cyclase 2). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Adcy2
Official Name
adenylate cyclase 2 [Source:MGI Symbol;Acc:MGI:99676]
Ensembl ID
ENSMUSG00000021536
Bio databases IDs NCBI: 210044 Ensembl: ENSMUSG00000021536
Aliases adenylate cyclase 2
Synonyms AC2, adenylate cyclase 2, HBAC2, KIAA1060, mKIAA1060
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adcy2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • qeha domain
  • enzyme
  • protein binding
  • magnesium ion binding
  • Adenylate cyclase, conserved domain
  • C2 domain (from adenylate cyclase)
  • binding protein
  • cytoplasmic domain
  • adenylate cyclase binding
  • adenylate cyclase
  • Class III nucleotidyl cyclases
  • cytosolic tail domain
  • Adenylyl- / guanylyl cyclase, catalytic domain
  • manganese ion binding
  • hydrophobic domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • myopathy
  • breast cancer
  • anxiety disorder
  • stress related disorder
  • bipolar disorder
  • non-small cell lung cancer
  • Huntington disease
  • bipolar I disorder
  • idiopathic scoliosis
  • morbid obesity
regulated by
  • methylanthraniloyl-adenosine 5'-[beta,gamma-imido]-triphosphate
  • isoproterenol
  • tetradecanoylphorbol acetate
  • forskolin
  • G protein beta gamma core
  • HTT
  • mantGppNHp
  • RAF1
  • 2'-(or-3')-O-(N-methylanthraniloyl)ATP
  • GNAS
regulates
role in cell
  • cell cycle progression
  • transformation
  • response by
  • doubling time

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • detergent resistant lipid raft fraction
  • Cytoplasm
  • cellular membrane
  • membrane rafts
  • perikaryon
  • dendrites

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Adcy2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
  • cAMP biosynthetic process
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway
  • cAMP-mediated signaling

Cellular Component

Where in the cell the gene product is active
  • dendrite
  • cytoplasm
  • membrane raft
  • membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • magnesium ion binding
  • ATP binding
  • manganese ion binding
  • adenylate cyclase binding
  • adenylate cyclase activity

Gene-Specific Assays for Results You Can Trust

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