Rbfox3 Gene Summary [Mouse]
Enables DNA binding activity. Predicted to be involved in nervous system development and regulation of alternative mRNA splicing, via spliceosome. Located in nucleus and perikaryon. Is expressed in dorsal root ganglion; nervous system; and sensory organ. Orthologous to human RBFOX3 (RNA binding fox-1 homolog 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbfox3 |
| Official Name | RNA binding protein, fox-1 homolog (C. elegans) 3 [Source:MGI Symbol;Acc:MGI:106368] |
| Ensembl ID | ENSMUSG00000025576 |
| Bio databases IDs | |
| Aliases | RNA binding protein, fox-1 homolog (C. elegans) 3 |
| Synonyms | CH17-351M24.1, D11Bwg0517e, FOX-3, HRNBP3, LOC100130312, LOC100133332, LOC101929831, LOC102723900, NEUN, Neuna60, RGD1560070, RNA binding fox-1 homolog 3, RNA binding protein, fox-1 homolog (C. elegans) 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbfox3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcitonin gene-related peptide regulator C terminal
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- covid-19 death
- infectious mononucleosis
- allergy
- acute myeloid leukemia
- benign rolandic epilepsy
- chronic pain
- chronic obstructive pulmonary disease
- endometriosis
- cleft palate with cleft lip
- herpes zoster
role in cell
- expression in
- migration
- invasion by
- regulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- intracellular space
- vesicles
- plasma membrane projections
- nucleoplasm
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbfox3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- regulation of alternative nuclear mRNA splicing, via spliceosome
- nervous system development
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- mRNA binding